The Manchester City goalkeeper made several key saves to help Gregg Berhalter’s side record a 2-0 victory over their fierce rivals at Cincinnati’s TQL Stadium.
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Steffen produced impressive stops to deny Edson Alvarez and Hirving Lozano in a goalless first half, before substitute Christian Pulisic headed home Timothy Weah’s cross to break the deadlock shortly after his introduction.
Weston McKennie made sure of the win five minutes from time, calmly slotting into the bottom corner from eight yards to secure three points which send the United States into pole position above Mexico at the halfway stage of the qualifying tournament.
In an end-to-end contest, Steffen had already got down well to keep out Alvarez’s effort when he made a crucial intervention to prevent Lozano giving the away side an early lead from a slick counter-attacking move.
The winger reached the edge of the area as he raced clear of the States’ defence, but the 26-year-old showed great reflexes to block his low drive with an outstretched foot as he recorded an 11th clean sheet for his country.
Steffen and the United States are next in action on Tuesday, when they face Jamaica in another World Cup qualifier at Independence Park in Kingston.